At HD distances (10 yards max in most homes) the sight height offset is going to be more of a factor than the range you're zeroed at. You're going to be holding 2ish" high regardless of where your zero is. No practical zero is going to compensate for that.
I'd zero for whatever range your predator hunting needs and then deal with the inevitable sight height offset.
This, plus the fact 2 inches won't matter at all ever in HD situations....and I doubt anyone would even remember to aim much at HD room defense situations.
Of course unless your rooms are in a multi million dollar house sized rooms. LOL
