There's a reason lot's of 3 gun guys use off set sights for close shots.

Not saying this is right or wrong but I prefer to think of it as an angle from the bore to meet up with line of sight at 100 yards. It's easier in my simple mind to say at 50 yards it's half the drop instead of I'm on at 50 but at 30 I'm low and at 80 I'm high. The difference is only at most 2.7" but that can make a miss if you're counting X's or hearts.

If all things stood out in the open, it would make no difference but life is not always so easy.

rost said "I don't know many that can consistently hit a 2 inch target in the heat of the moment anyway... chest cavity is big...."

That's why we practice and use as many advantages as we can get. Running a red dot on silhouettes is where this can be easily seen. It is still there in hunting situations but I think we tend to chalk it up to the tenacity of the critters will to live rather than we just missed the vitals.