I'm all for picking a hole in cover and shooting through that. And, yes, 6X scopes help alot, even at 50 yds.
I would add that if the shot does hit something, I've had better results with premium, fast opening bullets like the Nosler Partition than with fast opening cup and core bullets. C&C bullets tend to separate or deflect more readily in my experience.
It's also nice to have a fast follow up shot if the bullet tumbles.
Probably the toughest shooting I've ever had to do has been on running game in thick cover. E
