More than caliber, I aim for areas that will put the deer down NOW. I take base of neck and shoulder shots. The thick cedar swamp where I hunt oft times if a deer runs off and one is forced to wait until morning, you'll have a skeleton due to the coyotes. I've lately been gravitating to larger calibers too...favorites being a 303 Brit and 338 Federal.
I pick holes in brush, and aim VERY carefully with the intention of DRT.
