Since there seems to be a paucity of actual experience with Barnes Bullets - especially the 150gr .308 fired out of a 30-06 - actually used on game beyond 400 yards, why don't we try a little simpler method to answer his question?
I think most can agree that at impact velocities above 1800fps, the OP will likely be getting SOME expansion from the TTSX, but that a standard cup-and-core would likely do better in that relatively low-velocity situation.
The question then becomes, at what range does his 30-06's bullet drop below 1800fps?
Using the Hornady online ballistics calculator, I started off a 150gr .308 TTSX (B.C. = .420) at 2860fps. These are the results:
So if we use the cutoff point of 1800 fps, we see the OP can expect a minimum amount of expansion at his stated goal of 400-500 yards. However, he should be aware that with a 200 yard zero, the bullet will drop nearly FOUR FEET (45.2 inches) at 500 yards, which makes contacting the animal with a bullet a task I wouldn't want to undertake.
All that is necessary for the triumph of evil is that good men do nothing -- Edmund Burke
