The only big game I've shot with my 22-250 is an antelope. It has a 1-14 twist and I haven't experimented much to see how heavy I can go. For the antelope, I used 55gr Sierra Spire points. It entered the chest and nuked him. The heart and lungs were jello. I found the bullet in the far shoulder. It retained about 60% weight.

For mulies, the 22-250 weighs 1/2lb more than my 30-06 so there's no advantage in using it. The '06 with 165's is in another world.


β€œIn a time of deceit telling the truth is a revolutionary act.”
― George Orwell

It's not over when you lose. It's over when you quit.