Dan,
Here's the formula I use:
Pick the heaviest Nosler Ballistic tip your rifle can shoot at 3k+.
Above 3k, I generally switch to Accubonds.
NBT's at 3k, and Accubonds above are the closest thing I've found to "magic", DRT. Of course the big wound channel makes it easier to catch a piece of the CNS, which is the real key to turning anchoring your game in place.