Of all the deer I’ve killed or seen killed, a 300wby with factory 165 spire points (Hornady Interlocs) @3400 FPS has been the stand out on dozens of mule deer with shots averaging 300yds. 180g Sierra game kings @3200fps seemed nearly as effective. The things is, I’ve seen what the bullets do in or near the shoulder at close range...and it’s ugly and penetration is limited. I don’t see as many DRTs with partitions or accubonds but they remain my choice for all around performance.