In my experience the deciding factor is the animal itself. I've seen deer DRT and I've seen them run 100 yards from the same shot placement, bullet, and cartridge choices. Some give up easier than others.
This happened to me this year. Same cartridge, bullet and placement. Both didn't have hearts, but one was DRT, the other ran about 70 yards Midsize cartridge, under 3k, and not a frangible bullet.
