The biggest muley I've ever shot was with a .243 when I generally liked a .270/.280/.30/06 for that job. One shot over the heart with a 100 gr factory load did the trick. For about 10 years solid I shot a .338 since that is what Elmer liked. I bonded with that rifle more than any other. At that same time, the only other rifle I owned was my 1948 FN Mauser '06 which weighed about 10 lbs unloaded. Part of the reason I shot only the .338 for those 10 years was to see how it worked and part was because it was 2 lbs lighter than the '06.

To answer the OP.......yeah, sorta, maybe........for me it's like a series of 360's, not a 180. I'd like to get a .223 bolt gun at some point, but I just bought a Weibe bottom metal for a future .375 Ruger/FN Mauser. Never owned a .375 before and always heard everybody should at some point. By the way, I am 56 at this point. How silly is that?