I started in the late 60's with a 30/06,quickly got a 257 Roberts,then a 270.I used them all,at the same time used the 270;branched off into "all the others"...everything from 7x57,280,7/08,7 RM,various 300 magnums,338,375,etc,etc,still also hunting with the 270.Most carried, most used, were the 270,7 Rem Mag, and one or the other 300 magnum.Owned all the WSM's;never hunted them, but they are all gone.
It didn't seem to matter much what I carried;they all worked.
Today I only use the 270,the 7mm Mashburn Super, and the 375H&H...at least for the time being.
It is hard to beat a 270 for a combination of low to moderate recoil,flat trajectory and good killing effect(the 280 is its' twin,and I like it as well).
