I only have a personal experience base of two white tail deer killed with a .223 here on our farm here in KY. Both required a second shot for a finisher. Factory Rem 55gr Corelokts. OTOH, I have a significant string of one shot kills on the same deer, under the same conditions, with multiple .243 rifles and 95gr Partitions. No comparison.

I enjoy shooting accurate .223 target rifles. But here in my neck of the woods, if I absolutely, positively want it dead, the first time, the .243 gets the nod...