I'm a lefty. I took a left hand Ruger MKII and a Mauser M-98 to Africa in May. The Ruger proved to be heads and shoulders above the Mauser with it's low scope safety. Getting a live round back out, as my ride took off over the rocks, proved this, time, and time again. My P.H. made his point, that the big difference between the U.S. and Africa, is that you always reload instantly, and keep a live round in the chamber, until he says to unload the rifle. So the three position safeties are golden, between the occasional shots.