I've had a 300 Roy for 30 years and have shot about everthing in the West with it. Most several times, i.e. bull elk, mule deer, various kinds of sheep. I have always used Weatherby factory 180 grain Nosler Partitions. It is very flat and very deadly. Especially good for cross canyon shots on elk and deer. I had a 338 Win for several years and shot 225 grain Speer Grand Slams in it. I shot several bull elk with it in CO, NM, and AZ and it worked fine. One day in NM I was trying to make a long range shot, read 400 plus yards on a barbary sheep and it didn't work near as well as the 300 Weatherby. I thought recoil was a little worse on the 338 but it would be pushing a 225 grain bullet versus a 180 in the Wby. I'm just a 30 caliber guy when it comes to magnums. Better for all around hunting because you can use a 150 grain or 165 grain (best ballistic coefficient) if you want to.