Not sure where you are hunting but my opinion is the 270 would work but the 300 would be my choice. I understand the 270 is flatter however in most of the buffalo terrain I have hunted with exception to Tanzania there was not much opportunity for plainsgame at longer distances during the hunt. If it is a one rifle safari and you are hunting say Masailand I could understand the argument for a 270 grain bullet. However if you are hunting the Zambezi Valley per say then I see no benefit to a flatter trajectory as finding a shot over 200 yards is tough.