For what its worth, the last 3 Cape Buffalo hunted with us, the hunter used my .375H&H. It is loaded with 200gr GSC's doing around 3100fps.
The last bull took one shot, quartering towards. Ran 40yds, and collapsed.
So, either the 270 or 300's will work. My vote will be for the 270gr TSX.
All the best for your hunt and remember to post photos when you get back.
Take Care,
Marius Goosen
