I've only got one buffalo to my credit, so that's all my opinion is worth. I used the 300 grain TSX and it flattened my bull on the first shot and he did not regain his footing. I did put 4 or 5 solids into him to keep him from getting up. I am convinced though that if I had followed up with more TSX bullets instead of solids I would have needed to shoot less (and I had that hunch while shooting the buff).

Here is the inside of the buffalo. The hole you see in the middle is the entrance side of the shot.
[Linked Image]

And the bullet:
[Linked Image]

If you died tomorrow, what would you have done today ...