Most 5th wheels will require a 3/4 ton or bigger truck to pull.
We went with a bumper pull trailer (26')and a 1/2 ton. We use the truck for everyday driving and mileage is reasonable. (previous truck was a 3/4 ton diesel, a pulling beast but fuel and mtnce costs got pricey over it's life)
When we do lots of traveling, only stopping overnight or for a couple days, setting up and taking down is a bit of a pain, but not really that big a deal. We did 5000 miles in a month so experienced lots of overnighters!
Driving around town when you are hitched up is a bit of a pain, but not bad unless you are looking to park!
All of them are trade-offs, just a matter of which are acceptable to you. One thing for sure, don't buy a low end (read cheap) one, they will not last and repairs get old fast.