I've done both 5thwheel and truck campers. A 5thwheel is nice in terms of space, but you have to plan your camping spots and they are not very off road friendly. Towing doubles with a 5thwheel so you can take your boat is also a pain. Truck campers have limited space, but with a self contained camper you can camp about anywhere. It's also easier to haul toys behind a camper and they are the best choice offroad.
Currently it's just myself and my wife and most of the places we camp A truck camper or a tent is about the only options. Maybe when I retire and snowbird I'll get a toyhauler 5thwheel, but I will always have at least a small camper.
