I shoot 'em wherever looks like the closest path to the the top-of-heart-lung area, and they drop pretty quickly. Sometimes it's shoulder, sometimes it's lungs.
Both the Partition and BT have very soft front ends, and even though they typically retain 75-85% of their weight, even 15% of 250 grains is 37.5 grains of shrapnel. Due to the moderate velocity, however, they don't shoot up much meat, especially the 286.
The farthest I can recall a deer (or other deer-sized animal) going after being shot with either bullet is around 25 yards.
