I've used some 110s and factory 130's in the .308 and they are really destructive at full velocity. With reduced loads they start acting more like a pistol or 30M1 carbine bullet. Between the 2 I would go with the .22-250 and near full velocity loads. More chance of dropping the deer in it's tracks. The 223, 243, 260, & 7mm/08 are good choices too. Of these only the .223 would be noticeably quieter when wearing ear protection, which should be mandatory.