I also had my best luck in the standard Hornet with 30 VG's with H110. In fact it's my go-to Hornet powder for bullets lighter than 40 grains.
I don't want to give the impression that primers other than CCI 450's don't work with Li'l Gun. They do, in fact for years I used CCI BR-4's in my Ruger No. 1 because they worked the best of the small-rifle primers I had in stock then. But that was back when BR-4's weren't much more expensive than most other small-rifle primers. But then I ran a more complete test 4 years ago, and found 450's worked slightly better.
Interestingly, the Federal 205M, the primer used by most short-range benchrest shooters, didn't fare well in that test. Accuracy wasn't as good as with CCI BR-4's or 450's, and muzzle velocity was 100 fps slower than any other primer. However, benchrest shooters mostly use extruded powders that are more easily ignited than sphericals.
