That's exactly what I planned on using it for- 130's in my 270 and 180's in my 30/06. I already got a great shooting load in the 270 with RL26 and 140 grain Bergers. The RL16 might work pretty well for that as well. If it'll work in the 338 I could get by with only one powder, as that's all I load for, two 30/06's, 1 270 Win, and the 338.