..animals are in general sort of way made out of meat and meat-like substances. Since animals are killed by damage to the most immediately necessary bits, it stands to reason
that whatever does the most damage kills the fastest.
.257 or .375 well placed through the heart or brain of deer, those organs are going to stop working might fast regardless.
In the case of say substantially larger elephant hearts and brains .458 cal solids seem relatively minuscule and damage not that visually impressive.
size for size, .257 through a deers heart has a smaller ratio than .458 through an elephants.
