Hmmm, I have a .22-250 and a .243. Funny thing is, my .22-250 can't fling a 55 grain bullet 4000+ fps.... But my .243 can.... My .243 can also fling a 100 grain bullet 3000+ fps... But my .22-250 can't...
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A 243 with a 55 grain BT will smoke a 22- 250.
And sell barrels too. Really though just how much coyote hunting requires 4000 fps?