Your coyotes must be tougher than the ones I shoot! Haven't had a bit of trouble killing them with my 22-250 and I seldom load to top fps.
I won't say they're any tougher. I use the 223, 22-250, and 243 for coyote hunting, and have killed more with the 223 than anything else. I like shooting different rifles, and different cartridges. As I said, I've used a 223 more than anything else, but the 22-250 has it over the 223.......just like the 243 has it over the 22-250. I would be perfectly happy being able to use only one of those 3 for coyote hunting, if it ever boiled down to that. It's all about putting the bullet where it needs to go anyway, which brings us back to why the 243 is as good a choice for deer hunting as any, as long as you're able to just that.
