While I would not personally pick either one of these bullets, I have shot deer in the past with Sierra 130 grain and the deer seemed very dead when I was field dressing them. That said, I can't imagine not to able to put one down with either one of the bullets suggested. I would load them up in the 2800 fps neighborhood until I got the best accuracy and then go shoot something. The 270 is my all time favorite and while I have killed 9 elk and quite a few deer with that caliber I have only scratched the surface compared to MuleDeer, so I'd take his advice on the Hornady spire point
