I travelled from Taylor to Fairbanks in 1959, with my grandparents (I weas ten). We travelled in a 1953 Buick Special and went up and back with no issues whatsoever. At that time, there was no pavement between Fort St, John and the Alaska border. Now, the highway is pretty good with a lot more traffic. The only negative is that there are fewer fuel stops and places to eat. I would expect that most modern vehicles should be just as reliable as a six year old Buick Special.
We travelled between our home, in Taylor, and Ft. Nelson and up to Summit Lake, frequently.
When we drove up to Whitehorse, a few years back, we had pretty new tires on the Matrix and some camping gear in the back (along with the Airdale). For those "just in case" scenarios, there was a Lee Enfield and a box of 215 KKSP's, on the floor, in the back seat. Next trip, I will carry extra fuel; the Matrix tank is just too small. If we take the truck and trailer, I'll carry a slip tank. GD