HB,
If you're happy with that and its accurate, the like is commonly stated, no animal will be able to tell the difference in 100-150fps.
H4350 is a fine powder. You just wont maximize the .280Rem with it in bullet wts heavier than 120. You can come dang close with 140s, but still not IME. 150s and up IME require slower powders to get full potential. In this case with 160s and 162s, Id say 2800 from a 22" bbl will absolutely be max with 4350.
