I've had 2 45s on the larger Super Blackhawk Bisley frame, but my only experience with the Flattop "357" Bisley sized gun is in 44 Special with 265/270gr. bullets. Of course I've shot numerous 45's with the Ruger plow handle as well.
That said, the Bisley grip frame is a recoil champ, just don't do the death grip thing. Most who "like" the std plow handle aren't content with the OEM grips and are usually replaced by some rubber fist...
