I like the Ruger Bisley 45 Colt.. It is capable of everything from Mouse to Moose. The FA Model 97 limits you cartridge OAL to about 1.6 inches. The Colt SAA clones limit your chamber pressure. The older large frame Ruger Vaqueros are your best bets for fixed sight gun to shoot the heavier Buffalo Bore/Grizzily/Garrett 45s. You don't NEED to shoot the romper stompers but with the full size Rugers that is an option.
Garrett makes a Colt SAA(3rd gen) and Colt clone compatible cartridge that goes about 260 grains @ 900FPS that I would not be afraid to hunt any North American ungulate, black bear or other medium sized game with given the appropriate shot angle/distance.
