The biggest issues I've seen were weight, balance and stock fit.
A pal of mine that had drawn an elk tag and wanted a semi light .30. I did a really nice short Rem.700 with a 22" #2 barrel in 300WSM in the McMillan Sako Hunter. When it was done, I did the load work up.... it delivered honest 3/8"-1/2" three shot groups at 100 with an assortment of good hunting bullets using a scope that is dedicated for load work. I had given him some recommendations on scopes that would complete the package. Excitedly, he told me he was bringing the scope over for me to mount and sight in.
Like a proud new Dad, he reaches in a big box and produces a Nightforce NSX 5.5-22X50.
I could have cried.....
