You might lose 75-100 FPS, which will insure a bit more penetration-depending on the bullets used and the individual rifle.
With premium bullets like Swift-Woodleigh-Hawk, that's not a problem. You might have to slightly adjust Lyman
peep sight 56 or 66, or the original 98A Winchester bolt peep. Most of the moose and deer I have shot with the 348 were right at 90-100 yards
using the same stalk hunting that works for elk. This type of hunting is what the Model 71 in 348 WCF was designed for.
Keep in mind that the 348 cartridge is closer to the 35 Whelen than the parent 30-06 because of bullet diameter.