A guy that was working for me fell off a ladder a couple of weeks ago and broke his ankle - 3 breaks including a compound tibia fracture with frothy blood spurting out, dislocated shoulder, minor head injury. They gave him ketamine on the way to the trauma center and he, too, said that stuff sent him for a trip and he didn't want any more of it.
The surgeons were initially thinking that amputation may be his best bet, but decided to pin things up really good and hope for the best.