Bruce,
The big AccuBonds are pretty tough, in fact in my experience as tough as Partitions of the same weight. Know two people who've taken buffalo, no problem, with the 260 from the .375 H&H, one a charging bull. They hold together fine in the .375 Ruger as well.
I've shot a bunch of big game with the 250 9.3 from both the 9.3x62 and 9.3 B-S (same ballistics), including a 7-1/2 foot grizzly and plains game from gemsbok to kudu. The only one recovered was the second shot on the grizzly. The first one went broadside through the bear, entering just behind the left shoulder and exiting the meat of the right shoulder. The bear turned started running angling away. The second bullet entered the right rear ribs and was found under the hide on the left side of the neck, retaining over 80% of its weight. That was at about 50 yards.
