I believe I remember reading back in the day where Ross Seyfried completed a whole safari with 350gr TSX's and a 416, buffalo included, iirc, he came home and shot a bull elk at a hundred and some yards in a wallow too.
I hunted a handful of plains game on the same trip. The 416 was my only rifle and did fine on a decent kudu at 250 yards and others well over 100 yards. My buffalo was taken at 110 yards.
