I shot a 22-250 and 52 grain Amax's for years. It was pretty good out to around 450, but it didn't take a lot of breeze to blow them around past that point. I'm currently shooting the same rifle, a Cooper, with an 8 twist barrel and 75 grain ELD-M's. Took two prairie dogs last spring at 1127 and 1131 yards. These bullets buck wind pretty well.
There's a guy on here using the same twist in 22-250 shooting the 88gr ELDM. Frank at snipershide was using that bullet in the valkyre and shooting past a mile. But how can you argue with 1127 and 1131 yard PD's. Nice shooting!
