Depends on the cartridge for me, 300H&H full sized maybe 5 times, neck sized kept in the same rifle 20+. 6.5X55 50+ even with hot loads. 38 special, 45APC I gave up counting. Toss them when the neck splits. Never annealed any but I will trim rifles. Some are more forgiving than others. If they have to go into different rifles then I have found it is up to the individual chambers. I had two 243's that would not load each others fired cases unless really full sized.
