Late seeing this thread, but here goes. First, a .22-250 barrel is one of the two 788 barrels I would be leery of (.243 is the other). They can be shot out pretty easily if used for varmints. As stated above, the 788 can eat cases because of the rear locking lugs allowing bolt compression. I sold mine because it was a right hand action and I am a lefty. I think before I rebarreled I would have the barrel borescoped and if the throat was burned out, I would have a smith cut the barrel back to 22 inches or so if possible.