Turned down a full stock M77 back when I was young, dumber, and poor. It's been eating at me every since. Then the family got me a M99R 250 for my 50th birthday, made in 1953 same as me. I've taken several deer with the 87 Speer Hot Core and a couple with the 100 Hot Core in that rifle. These days I've settled on Big Game with the Hot Core and RL-15 with the 87 TNT, they shoot to the same point of aim in this rifle, so I can interchange depending on what I'm hunting.
A few years ago Cheesy ran across a Ruger M77 Tang Safe 250 with a Timney trigger consigned at a local gun shop. I ended up buying it and have been real happy with it. The earlier mentioned 35-H4895 load with the 100 Speer Hot Core did a number on a large buck here on my place last fall. A few days later the M99 and the 87 Hot Core dropped a doe. Freezer was full.