I hunt with this exact same set up.......you'll like the H4350 better IMO.....I'd start about 41.5 gr and work up, depending on the lot I can get upwards of 43.0gr and just under 2900fps from my 22" barrel. The LRX hammers to about 600 yds then the Bergers and Horndady ELD's take over but the 127 LRX will reliably preform.....I've taken 2 coues bucks with this set combo.....if your going past 600 by design then I'd choose something more than the creedmoor.