I read an article by a doctor who specialized in genetic diseases. He did a lot of work with the Amish. They marry within their religion and there aren't enough of them for good genetic variation. He'd identified something like 120 genetic diseases in the Amish caused by marrying 1st cousins.

“In a time of deceit telling the truth is a revolutionary act.”
― George Orwell

It's not over when you lose. It's over when you quit.