My wife's Uncle was married to my Aunt, so their kids are first cousins to each of us. Although she and I share absolutely no ancestry.
But still we do get teased a lot, even by our children.
We had a female clerk at the factory, who was a couple cards shy of a full deck. After yet another ridiculous blunder she would blather for a minute about, "It ain't my fault, my parents was first cousins."
The genetic blunder left her a bit shy in the smarts dept. But she was blessed in ways that would have greatly pleased even Jorge.