I've had a few of both and prefer the hmr. Not sure I've noticed a big difference in killing power, but I definitely noticed a difference in accuracy. Seems every hmr I've had has been a tackdriver out to 125-150 yards. Every 22mag has been ok to about 50 yards then the groups open up tremendously after that. Only reason I'd go for a 22mag now would be if I needed a heavier bullet for close-in larger game.