I loaded some Cast Performance 180gr WNFPGC bullets with a max charge of H110 for hog protection. I haven't used them on an animal but they sure hit steel swingers hard out of my M65 4". I know an avid bear hunter and he doesn't recommend HPs for bear. In his experience they didn't penetrate deep enough.
https://www.grizzlycartridge.com/shop/cast-performance-bullets/38-180gr-wfngc-358-dia-100-count/