If we are talking most American CF's I would be inclined to agree with jwall's list. 30-06 has killed many of our foreign enemies. Its a cartridge that we've all probably owned and love (I have two). A close second would be the 30-30. Its fed alot of American's also. The first CF's I bought my kids were all 30-30's. Third would be 45 colt because it's in almost every western and has a neat place in American law/outlaw history. I own one also.
