Had a Core loktt deflect on a rib shot at a bad angle, had excessive meat loss with Nosler Solid base, early Ballistic Tips, and early SSts. Only bullet that I might not use again is the Berger VLD. If I knew shots would be at 300 + yards they would be great, at closer ranges there is too much blood shot meat and even with clean looking cuts there was still lead in the meat. I can't really say I have had an out right failure with any bullet just some didn't perform as hoped.