When I lived in eastern Washington I used primarily three centerfires for coyotes. A 220 Swift with the 52 grain Speer 1035 HP driven hard, a 17 Remington with 25 grain Hornady HPs and a 222 with either 50 grain Hornady SX or Speer 50 grain Spitzer. I always hunted for fur. The 52 grain Speer HP likes to be driven fast if it’s going to be a fur bullet. A friend whom I was skinning for tried them in a 223 and found he had large exit wounds with it. I rarely had an exit with that bullet from a Swift nor did my calling partner with his 22-250. The 17 never had an exit unless I made a fringe hit. The 222 piled up a lot of coyotes. Either bullet did well with only very rare exits. I started using the Sierra 1365 GK 55 grain some and liked it. Tougher bullet and does leave an exit but normally only an inch hole. Works in either the Swift or 222.
So yes the 222 works well for coyote, especially in the parameters you specified.
