NYC law enforcement found a Key ingredient into one shot stops in the 30's with a 190g and 200g SWC loaded to +P velocities in the 700-800 fps, all that heavy Winter Clothing took a heavy bullet.

My brother in law was with LAPD, shot a guy five times in the chest with his 38 duty weapon, and the guy kept coming, partner had to dispatch the guy with a shot gun. A good friend was with Atlanta Police, first day on the job. He had to shoot a bank robber 6 times with his 38, and he survived.

Bullets have dramatically improved since this time, but nothing trumps shot placement.