Good Question. Complicated Answer.
1) Most Alaskan guides are no longer Alaskans.
2) Ed was a mountain man who lived and guided in puckerbrush. Those rifles worked great in his guide areas.
3) Some guides take rifle functionality as a primary element of a rifle. Many of these guides are longer in the tooth but can run a peep or run a scope to great effect.
4) Many guides run rugers. Try to find a boat paddle 77 in 338 or 300 win for sale. There are a lot of Ruger guide guns in 338 Win or 375 Ruger.
5) A lot of sheep and mountain game guides run Kimber montanas.
6) Moose guides will run Marlin 1895s in 45-70.

A lot clients are bringing up Gunwerks, Christiansens and other custom carbon fiber barreled and stocked rifles. There are some really funny stories about their performance. A lot of people know that its the Indian and not the arrow and you can't buy shooting proficiency.